Nombre: Cadena lateral de semaglutida; Modificador del éster activo de semaglutida; Éster activado por NHS de cadena lateral de semaglutida

Abreviatura del producto: tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu

Número CAS: 1118767-15-9

Código de producto: 06040003000

Almacenamiento: -20±5°C

La cadena lateral de semaglutida (tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu) es un grupo protector crucial para las cadenas laterales en la síntesis de péptidos. Presenta una excelente solubilidad y estabilidad, protegiendo eficazmente las cadenas laterales de aminoácidos de modificaciones no específicas o degradación durante reacciones químicas. Ampliamente utilizada en la síntesis de péptidos en fase sólida y modificaciones posteriores de grupos funcionales, la cadena lateral de semaglutida ayuda a controlar las condiciones de reacción y la selectividad, minimizando las reacciones secundarias para mejorar la pureza y el rendimiento del producto.

I. Aplicaciones

1. Drug Modification: tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu is utilized in modifying small molecule drugs, proteins, antibodies, and other bioactive molecules. By forming stable amide bonds, it enhances drug solubility, stability, or targeting specificity, thereby improving therapeutic efficacy and safety. Particularly significant in the development of long-acting peptide drugs like Semaglutide, it plays a critical role in optimizing pharmacokinetic properties and therapeutic effects.

2. Targeted Drug Delivery: Leveraging its high reactivity and biocompatibility, tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu is employed in constructing targeted drug delivery systems. This facilitates precise drug release within specific tissues or cells, enhancing therapeutic efficacy while reducing side effects.

3. Biological Probes and Diagnostic Reagents: As a component of biological probes or diagnostic reagents, this compound can detect specific molecules or cellular activities within organisms, providing robust support for disease diagnosis and treatment.

II. Production and Storage

Production: The production of tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu is typically carried out by specialized pharmaceutical intermediate manufacturers equipped with advanced synthesis technologies and stringent quality control systems.

Storage: It is recommended to store tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu at -20°C to ensure stability and activity.

III. Supplier Information

Currently, multiple suppliers, including but not limited to Xiamen Sinobestech Biotechnology Co., Ltd., offer tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu. These suppliers possess extensive production experience and rigorous quality control processes, ensuring high-quality products and excellent service for customers.

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