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| Common Name | Amino-Tetraethylene Glycol-Hydroxy |
| CAS Number | 86770-74-3 |
| Molecular Formula | C₈H₁₉NO₄ |
| Molecular Weight | 193.2 g/mol |
| Structural Feature | Composed of 4 ethylene glycol units (PEG4), with an amino group (-NH₂) at one end and a hydroxyl group (-OH) at the other. |
Core Characteristics and Applications
Its core value lies in the functional groups at both ends and the PEG spacer in the middle:
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Amino End (-NH₂): It is nucleophilic and can react with carboxyl groups, active esters, etc. It is commonly used to conjugate proteins, peptides, or modify solid surfaces.
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Hydroxyl End (-OH): It has certain reactivity and can be further derivatized, such as through esterification.
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PEG4 Spacer: Provides a flexible spacer arm of approximately 15-18 Å, which helps reduce steric hindrance between coupled molecules and enhances their water solubility and biocompatibility.
Based on these properties, NH2-PEG4-OH is primarily used in the following fields:
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Drug Delivery: Serves as a linker arm connecting antibodies and toxins in Antibody-Drug Conjugates (ADCs).
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Bioconjugation and Modification: Used to modify proteins, peptides, or nanoparticles to improve their water solubility and stability.
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Material Synthesis: Acts as a linker unit or starting material for synthesizing polymer materials, hydrogels, or functional coatings.
